Cure Insight
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Research Corner: Helping the Pancreas Help Itself
Dr. Claresa Levetan explains how activating a regenerative gene may be the key for T1s to start producing insulin again.
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Can Neuropathy Be Cured?
University of Virginia researchers use an enzyme to reverse neuropathy in mice.
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Ending the A1C Blame Game
When a diabetes researcher wears a glucose sensor, she is reminded that diabetes is mainly physiological.
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Can We Teach an Old Pancreas New Tricks?
Researchers find that most people with T1 diabetes still produce a low level of insulin.
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The Mouse Trap
We’ve gotten good at curing diabetes in mice. Where’s the cure for humans?
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Is a T1 Vaccine Coming Soon?
Finnish researchers say they’ve found the virus that causes T1 diabetes.
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Sleeping Betas Get a Wakeup Call
An autoimmune response by unregulated T-lymphocytes kills insulin-producing beta cells. New research with low-dose IL-2 therapy shows promise in rebalancing the immune system and restoring normal pancreatic function.
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Reverse Vaccine for Diabetes Shows Promise
Can scientists use a new molecule to shut off the immune system’s attack on islet cells? Results of a new trial with human volunteers look promising.
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The Cure is in Us
Dr. Claresa Levetan has promised 11-year-old Type 1 Louis Cocco, Jr. that she will get him off insulin before he is a grownup. He believes it, and she can back it up.
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Good News, Bad News: TrialNet’s Bittersweet World
96% of children in T1 families lack the antibodies that predict they will develop Type 1 diabetes. TrialNet provides peace of mind to most of its trial participants and helps the 4% who are genetically disposed to Type 1 receive…
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Study Seeks Environmental Factors to Type 1 Diabetes
Australian researchers want to interview 1400 mothers to see if lifestyle and diet might affect rates of Type 1 diabetes in children.
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ADA Scientific Sessions 2013: A Pause Before The “Next Big Thing”
Every year since 1940, the American Diabetes Association has brought doctors, researchers, clinicians, and industry together for an annual event they call the Scientific Sessions. The name is apt. This is a serious gathering, not an excuse to party, and…
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Four-Legged Islet Factories: The Pigs of Auckland Island
A herd of pigs from a remote island in the south Pacific Ocean hold the promise of a virtually endless supply of beta cell-filled islets. The breeder, Living Cell Technologies, hopes to create a demand for islet transplants as long-term…
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Putting Killer Cells in Reverse: The Hidden Power of CXCL12
Poznansky has developed a process to keep “killer” cells away from transplanted tissue, specifically islets, by deceiving them into not recognizing new tissues containing beta cells as foreign.
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A Type 1 Triple Play
What if we could forecast which people would suffer from Type 1 diabetes years before it happened?
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Mending Metabolism
Bariatric surgery early in the course of a patient’s diabetes is far more likely to produce remission, and sustained improvements in blood pressure and cholesterol levels, than the same procedure performed as a “last resort.”
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The Hygiene Hypothesis: Too Clean for Our Own Good?
The tiny eggs of pig whipworms may be key in slowing down Type 1 diabetes, and preventing it altogether in children at risk of the disease.
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Stemming the Tide of Immune Response
Delivering mesenchymal stem cells (MSCs) during islet transplantation more than doubled islet function, enhanced islet survival and reversed rejection episodes. Embedded in the DRI’s recently announced BioHub “mini organ,” MSCs could lead to long-lasting or even permanent cures for people…
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Small Wonders On A Cellular Battlefield
“We’re exploring using materials that release, slowly, low amounts of drugs at the implant site for many years. Instead of a future with daily pills or injections, it’s feasible to have patients come in every three, five or seven years…
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A Safe House for Islets
“The BioHub is a localized micro-environment,” said Ricordi. “It is a quantum leap in cell therapy to replace insulin-producing cells that are destroyed by diabetes.” Is this the breakthrough we’ve been waiting for?
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