Treatment of Type 1 Diabetes

  • Tandem gets first ACE Pump Designation from FDA

    The U.S. Food and Drug Administration says the Tandem Diabetes Care t:slim X2™ insulin pump now has an interoperable designation. “Diabetes is a complicated disease that requires close monitoring and carefully tailored treatments. We’ve heard from the patient community that…

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  • PKvitality CGM K’Watch is Exciting

    We spoke with PKvitality leaders Minh Lê, General Manager, and Tom Bishop, CTO Medical. They shared their investor slide deck and we have included selected images in this article. CGM Reimagined The PKvitality team wants to disrupt the existing CGM…

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  • SGLT2 inhibitors are Promising Medications for T1D but Vigilance Required

    This article was written with a lot of help from Brad, a clinical pharmacist and pharmacotherapy specialist working in a hospital with a practice focus on diabetes.  Brad is also a T1Dad to an amazing 3rd grader. Why Understanding SGLT2…

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  • JDRF Open Protocol — Path to Better Future

    In 2018, JDRF celebrated the first anniversary of its Open Protocol initiative to support the development of automated insulin delivery systems, including artificial pancreas (AP) algorithms, continuous glucose monitors (CGM) and insulin pumps.  The goal is to increase the ability…

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  • MannKind is Fixing Foundations to Build a Big Future

    Michael is a pharmacist by training and a turnaround expert with a strong record of healthcare innovation.  He described the progress that MannKind has made since he joined the company in 2016. MannKind describes themselves a biopharmaceutical company that focuses…

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  • Food Effect on Glucose

    Modeling Food to Glucose Process Many physiologic processes in the body have been described with a model-based structure. Insulin absorption was modeled as early as 1959, and compartment models for it followed. Insulin’s effect on glucose was modeled with compartment…

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  • A Systems Approach to T1D Care

    Diabetes care is especially complex for T2D because there are a lot of variables that impact the effect of food, insulin, and exercise on blood glucose. Fortunately for Type 1 diabetes, the body’s food and insulin inputs, and the resulting…

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  • Using CGMs, Insulin Pens, and Pumps

    How to interpret CGM for BG control Continuous glucose monitors provide a wealth of information that may be used tactically to improve BG control.  Some of this is provided right on a Dexcom CGM receiver by the “trend arrow” that…

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  • Bolus Insulin Management in T1D

    Bolus insulin is the insulin you take for food What you eat is digested in stages; some is absorbed right in the mouth, which is what makes honey the best thing to use for a serious hypoglycemic emergency.  Honey is…

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  • Physiology of Managing T1D

    Glucose measurement technology has advanced and this has enabled the control strategies that can be used today. Introduction Our body needs the energy to work, and there are just a few ways for cells to get that energy: oxidizing (burning)…

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  • Acronyms and References

    Acronyms and References   amylin https://en.wikipedia.org/wiki/Amylin AndriodAPS https://androidaps.readthedocs.io/en/latest/EN/ Aspart https://en.wikipedia.org/wiki/Insulin_aspart Automated insulin delivery https://diatribe.org/automated-insulin-delivery BG (Blood Glucose) https://en.wikipedia.org/wiki/Blood_sugar_level blood plasma https://en.wikipedia.org/wiki/Blood_plasma C-Peptide https://www.webmd.com/diabetes/what-is-c-peptide-test#1 cannula https://en.wikipedia.org/wiki/Cannula capillary https://en.wikipedia.org/wiki/Capillary carbohydrate https://en.wikipedia.org/wiki/Carbohydrate CF (correction factor) https://www.healthline.com/health/insulin-sensitivity-factor#calculating-the-factor CGM https://en.wikipedia.org/wiki/Continuous_glucose_monitor cohort https://en.wikipedia.org/wiki/Cohort_(statistics) CSII http://diabetes-mellitus.org/csii.htm dawn…

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  • Basal insulin Management in T1D

    Overview The current insulin regimen for glucose management is called basal-bolus, named after its two components: Basal—background insulin reflecting second phase insulin release from a healthy pancreas Bolus—prandial insulin for the first phase, meal-related, dose. “fast acting” Regular insulin was…

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  • Engineer hacks Diabetes – Part 2

    Systems Education I was always technically inclined, and majored in physics in college, then did graduate work in Cybernetic Systems. Cybernetics has come to mean computer and internet related technology, but when it was first used in the 1940s it…

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  • Dexcom is Excited, and Best is yet to Come

    How do you see CGM devices evolving? The foundation of our product development is that we want our products to: Perform well and accurately measure blood glucose Be convenient to use and fit within the patient’s life — for example,…

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  • CGM Sensors are good and getting even better

    CGM's are getting better.

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  • Tidepool Loop Gets $6M Boost from JDRF/Helmsley

    JDRF and The Helmsley Charitable Trust announced collaborative grant agreement to provide Tidepool with the funding needed to begin developing Tidepool Loop. This is a vote of confidence and displays tangible support for Tidepool’s effort to deliver an FDA-regulated version…

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  • The new Insulin pill breakthrough

    Oral delivery of insulin has been actively researched for decades.  Injections are painful and inconvenient. People often delay starting insulin therapy because they don’t want injections.  Oral therapy would increase patient compliance. Oramed and Rani Therapeutics are early leaders in…

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  • Basal Insulin Management is not easy. These new tools could help

    When people with Type 2 Diabetes start basal insulin treatment, the goal is to reach a lower fasting glucose target. Each person gets an initial insulin dose and the expectation is that this dosage will gradually increase until the fasting…

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  • Yes, you should share your CGM & Pump data with Tidepool

    “Making diabetes data more accessible, meaningful, and actionable” is the Tidepool mission.   This not-for-profit organization began with a father’s effort to get data from his daughter’s CGM and Pump. This quest led Tidepool to create a free software solution…

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  • Diabeloop Artifical Pancreas Closer to Release

    Diabeloop has made rapid progress since its founding in 2015 and has achieved an important milestone with receipt of CE marking in Europe.  This positions this closed-loop system for commercial release in 2019. “ With this certification, we’re getting closer…

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