Treatment of Type 1 Diabetes

  • Overnight Dosing Success in T1D Children

    We spoke with Ulrike Schierloh, MD who is with the Pediatric Clinic, Centre Hospitalier de Luxembourg, Luxembourg, GD de Luxembourg about the study that was just published in PLOS|One. Study Overview This study obtained glucose levels as well as plasma…

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  • Basal Insulins Explained

    Many people with diabetes have developed a love-hate relationship with insulin. This life-saving, wallet-shrinking, high-fixing, low-causing, pain-to-dose wonder molecule is a mainstay of diabetes care. There are many flavors of insulin out there so let’s start by breaking down the…

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  • Better Insulin Dosing via Machine Learning

    We spoke with Cyndi Williams, Co-Founder and CEO of Quin — https://quintech.io — about their Insulin Intervention Taxonomy and how these data sets produce better T1D insulin dosing recommendations. Quin believes that self-care T1D insulin-dosing strategies derived from each individual’s…

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  • Bolus Dosing Skills that you Didn’t Learn in the Doctor’s Office

    Carbohydrate counting (or carb counting) is a traditional method for mealtime insulin dosing. It utilizes insulin to carb ratios for calculating meal doses. The Insulin-Carb ratio has been taught for years and is a decent method for dosing insulin based…

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  • Medtronic 670G Faulted for Ease of Use

    “Closed-loop insulin pump therapy is the most exciting new development in type 1 diabetes in decades because it acts as an artificial pancreas,” said co-lead investigator Gregory Goodwin, M.D., a senior associate physician in medicine at Boston Children’s Hospital in…

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  • FDA Rejects SGLT Drug Zynquista for T1D Use

    The FDA declined to approve Zynquista a drug developed by Sanofi SA and Lexicon Pharmaceuticals intended for use with insulin in patients with Type 1 Diabetes.  The generic name of the drug is sotagliflozin. The decision comes about two months after…

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  • Alertgy’s Non-Invasive CGM Wristband

    We spoke with Marc Rippen, co-founder and President of Alertgy, a startup founded in 2016 and based in Melbourne, Florida.  Marc and his team have strong backgrounds in the defense industry and are applying expertise to CGMs that was developed…

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  • Tandem gets first ACE Pump Designation from FDA

    The U.S. Food and Drug Administration says the Tandem Diabetes Care t:slim X2™ insulin pump now has an interoperable designation. “Diabetes is a complicated disease that requires close monitoring and carefully tailored treatments. We’ve heard from the patient community that…

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  • PKvitality CGM K’Watch is Exciting

    We spoke with PKvitality leaders Minh Lê, General Manager, and Tom Bishop, CTO Medical. They shared their investor slide deck and we have included selected images in this article. CGM Reimagined The PKvitality team wants to disrupt the existing CGM…

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  • SGLT2 inhibitors are Promising Medications for T1D but Vigilance Required

    This article was written with a lot of help from Brad, a clinical pharmacist and pharmacotherapy specialist working in a hospital with a practice focus on diabetes.  Brad is also a T1Dad to an amazing 3rd grader. Why Understanding SGLT2…

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  • JDRF Open Protocol — Path to Better Future

    In 2018, JDRF celebrated the first anniversary of its Open Protocol initiative to support the development of automated insulin delivery systems, including artificial pancreas (AP) algorithms, continuous glucose monitors (CGM) and insulin pumps.  The goal is to increase the ability…

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  • MannKind is Fixing Foundations to Build a Big Future

    Michael is a pharmacist by training and a turnaround expert with a strong record of healthcare innovation.  He described the progress that MannKind has made since he joined the company in 2016. MannKind describes themselves a biopharmaceutical company that focuses…

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  • Food Effect on Glucose

    Modeling Food to Glucose Process Many physiologic processes in the body have been described with a model-based structure. Insulin absorption was modeled as early as 1959, and compartment models for it followed. Insulin’s effect on glucose was modeled with compartment…

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  • A Systems Approach to T1D Care

    Diabetes care is especially complex for T2D because there are a lot of variables that impact the effect of food, insulin, and exercise on blood glucose. Fortunately for Type 1 diabetes, the body’s food and insulin inputs, and the resulting…

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  • Using CGMs, Insulin Pens, and Pumps

    How to interpret CGM for BG control Continuous glucose monitors provide a wealth of information that may be used tactically to improve BG control.  Some of this is provided right on a Dexcom CGM receiver by the “trend arrow” that…

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  • Bolus Insulin Management in T1D

    Bolus insulin is the insulin you take for food What you eat is digested in stages; some is absorbed right in the mouth, which is what makes honey the best thing to use for a serious hypoglycemic emergency.  Honey is…

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  • Physiology of Managing T1D

    Glucose measurement technology has advanced and this has enabled the control strategies that can be used today. Introduction Our body needs the energy to work, and there are just a few ways for cells to get that energy: oxidizing (burning)…

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  • Acronyms and References

    Acronyms and References   amylin https://en.wikipedia.org/wiki/Amylin AndriodAPS https://androidaps.readthedocs.io/en/latest/EN/ Aspart https://en.wikipedia.org/wiki/Insulin_aspart Automated insulin delivery https://diatribe.org/automated-insulin-delivery BG (Blood Glucose) https://en.wikipedia.org/wiki/Blood_sugar_level blood plasma https://en.wikipedia.org/wiki/Blood_plasma C-Peptide https://www.webmd.com/diabetes/what-is-c-peptide-test#1 cannula https://en.wikipedia.org/wiki/Cannula capillary https://en.wikipedia.org/wiki/Capillary carbohydrate https://en.wikipedia.org/wiki/Carbohydrate CF (correction factor) https://www.healthline.com/health/insulin-sensitivity-factor#calculating-the-factor CGM https://en.wikipedia.org/wiki/Continuous_glucose_monitor cohort https://en.wikipedia.org/wiki/Cohort_(statistics) CSII http://diabetes-mellitus.org/csii.htm dawn…

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  • Basal insulin Management in T1D

    Overview The current insulin regimen for glucose management is called basal-bolus, named after its two components: Basal—background insulin reflecting second phase insulin release from a healthy pancreas Bolus—prandial insulin for the first phase, meal-related, dose. “fast acting” Regular insulin was…

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  • My T1D Journey as a Systems Engineer

    Systems Education I was always technically inclined, and majored in physics in college, then did graduate work in Cybernetic Systems. Cybernetics has come to mean computer and internet related technology, but when it was first used in the 1940s it…

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