Treatment

SGLT2 inhibitors are Promising Medications for T1D but Vigilance Required

SGLT2 inhibitors are Promising Medications for T1D but Vigilance Required

This article was written with a lot of help from Brad, a clinical pharmacist and pharmacotherapy specialist working in a hospital with a practice focus on diabetes.  Brad is also a T1Dad to an amazing 3rd grader. Why Understanding SGLT2…
JDRF Open Protocol — Path to Better Future

JDRF Open Protocol — Path to Better Future

In 2018, JDRF celebrated the first anniversary of its Open Protocol initiative to support the development of automated insulin delivery systems, including artificial pancreas (AP) algorithms, continuous glucose monitors (CGM) and insulin pumps.  The goal is to increase the ability…
MannKind is Fixing Foundations to Build a Big Future

MannKind is Fixing Foundations to Build a Big Future

Michael is a pharmacist by training and a turnaround expert with a strong record of healthcare innovation.  He described the progress that MannKind has made since he joined the company in 2016. MannKind describes themselves a biopharmaceutical company that focuses…
Food Effect on Glucose

Food Effect on Glucose

Modeling Food to Glucose Process Many physiologic processes in the body have been described with a model-based structure. Insulin absorption was modeled as early as 1959, and compartment models for it followed. Insulin’s effect on glucose was modeled with compartment…
A Systems Approach to T1D Care

A Systems Approach to T1D Care

Diabetes care is especially complex for T2D because there are a lot of variables that impact the effect of food, insulin, and exercise on blood glucose. Fortunately for Type 1 diabetes, the body’s food and insulin inputs, and the resulting…
Using CGMs, Insulin Pens, and Pumps

Using CGMs, Insulin Pens, and Pumps

How to interpret CGM for BG control Continuous glucose monitors provide a wealth of information that may be used tactically to improve BG control.  Some of this is provided right on a Dexcom CGM receiver by the “trend arrow” that…
Bolus Insulin Management in T1D

Bolus Insulin Management in T1D

Bolus insulin is the insulin you take for food What you eat is digested in stages; some is absorbed right in the mouth, which is what makes honey the best thing to use for a serious hypoglycemic emergency.  Honey is…
Physiology of Managing T1D

Physiology of Managing T1D

Glucose measurement technology has advanced and this has enabled the control strategies that can be used today. Introduction Our body needs the energy to work, and there are just a few ways for cells to get that energy: oxidizing (burning)…
Acronyms and References

Acronyms and References

Acronyms and References   amylin https://en.wikipedia.org/wiki/Amylin AndriodAPS https://androidaps.readthedocs.io/en/latest/EN/ Aspart https://en.wikipedia.org/wiki/Insulin_aspart Automated insulin delivery https://diatribe.org/automated-insulin-delivery BG (Blood Glucose) https://en.wikipedia.org/wiki/Blood_sugar_level blood plasma https://en.wikipedia.org/wiki/Blood_plasma C-Peptide https://www.webmd.com/diabetes/what-is-c-peptide-test#1 cannula https://en.wikipedia.org/wiki/Cannula capillary https://en.wikipedia.org/wiki/Capillary carbohydrate https://en.wikipedia.org/wiki/Carbohydrate CF (correction factor) https://www.healthline.com/health/insulin-sensitivity-factor#calculating-the-factor CGM https://en.wikipedia.org/wiki/Continuous_glucose_monitor cohort https://en.wikipedia.org/wiki/Cohort_(statistics) CSII http://diabetes-mellitus.org/csii.htm dawn…
Basal insulin Management in T1D

Basal insulin Management in T1D

Overview The current insulin regimen for glucose management is called basal-bolus, named after its two components: Basal—background insulin reflecting second phase insulin release from a healthy pancreas Bolus—prandial insulin for the first phase, meal-related, dose. “fast acting” Regular insulin was…
My T1D Journey as a Systems Engineer

My T1D Journey as a Systems Engineer

Systems Education I was always technically inclined, and majored in physics in college, then did graduate work in Cybernetic Systems. Cybernetics has come to mean computer and internet related technology, but when it was first used in the 1940s it…
Dexcom is Excited, and Best is yet to Come

Dexcom is Excited, and Best is yet to Come

How do you see CGM devices evolving? The foundation of our product development is that we want our products to: Perform well and accurately measure blood glucose Be convenient to use and fit within the patient’s life — for example,…
Tidepool Loop Gets $6M Boost from JDRF/Helmsley

Tidepool Loop Gets $6M Boost from JDRF/Helmsley

JDRF and The Helmsley Charitable Trust announced collaborative grant agreement to provide Tidepool with the funding needed to begin developing Tidepool Loop. This is a vote of confidence and displays tangible support for Tidepool’s effort to deliver an FDA-regulated version…
The new Insulin pill breakthrough

The new Insulin pill breakthrough

Oral delivery of insulin has been actively researched for decades.  Injections are painful and inconvenient. People often delay starting insulin therapy because they don’t want injections.  Oral therapy would increase patient compliance. Oramed and Rani Therapeutics are early leaders in…
Basal Insulin Management is not easy. These new tools could help

Basal Insulin Management is not easy. These new tools could help

When people with Type 2 Diabetes start basal insulin treatment, the goal is to reach a lower fasting glucose target. Each person gets an initial insulin dose and the expectation is that this dosage will gradually increase until the fasting…
Yes, you should share your CGM & Pump data with Tidepool

Yes, you should share your CGM & Pump data with Tidepool

“Making diabetes data more accessible, meaningful, and actionable” is the Tidepool mission.   This not-for-profit organization began with a father’s effort to get data from his daughter’s CGM and Pump. This quest led Tidepool to create a free software solution…
Diabeloop Artifical Pancreas Closer to Release

Diabeloop Artifical Pancreas Closer to Release

Diabeloop has made rapid progress since its founding in 2015 and has achieved an important milestone with receipt of CE marking in Europe.  This positions this closed-loop system for commercial release in 2019. “ With this certification, we’re getting closer…
The Senseonics Eversense CGM could Surprise & Delight Users

The Senseonics Eversense CGM could Surprise & Delight Users

The Eversense CGM system consists of an implanted sensor, a removable transmitter, and a smartphone app. CGM adoption has been slower than expected with less than 30% of T1D people using CGM devices even though they have been available for…
Pump Innovator is Ideal Pharma/Device Partner

Pump Innovator is Ideal Pharma/Device Partner

SFC Fluidics has used a succession of SBIR grants and a recent partnership with JDRF to develop a patch pump that complies with JDRF’s Open-Protocol Automated Insulin Delivery (AID) Systems Initiative. I spoke with Tony Cruz, CEO, and Ashley Shemain,…
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